NYC2123 is a graphic novel conceived for the 480 by 272-pixel screen of the Play Station Portable video game device. It’s a post-apocalyptic tale set in a future, tsunami-ravaged New York in which the city’s wealthy have walled off the island of Manhattan against a violent river society of junkies, thieves and outlaw barges.
There are several sequences that read like a flip book, taking advantage of the single-frame interface and the fact that the reader has literally got his finger on the button. Quickly flipping through the panels creates a filmic effect, as here:

(Once again via Infocult – thanks Bryan)
Update: Someone has just developed a .pdf reader for the PSP.