The American Council of Learned Societies has just issued a report, “Our Cultural Commonwealth,” assessing the current state of scholarly cyberinfrastructure in the humanities and social sciences and making a series of recommendations on how it can be strengthened, enlarged and maintained in the future.
The definition of cyberinfastructure they’re working with:

“the layer of information, expertise, standards, policies, tools, and services that are shared broadly across communities of inquiry but developed for specific scholarly purposes: cyberinfrastructure is something more specific than the network itself, but it is something more general than a tool or a resource developed for a particular project, a range of projects, or, even more broadly, for a particular discipline.”

I’ve only had time to skim through it so far, but it all seems pretty solid.
John Holbo pointed me to the link in some musings on scholarly publishing in Crooked Timber, where he also mentions our Holy of Holies networked paper prototype as just one possible form that could come into play in a truly modern cyberinfrastructure. We’ve been getting some nice notices from others active in this area such as Cathy Davidson at HASTAC. There’s obviously a hunger for this stuff.